this is just my opinion.
i have a top 40 edm remixes etc set on friday and tech, tech house, deep house, house set on saturday. the one thing i have noticed is spinning top 40 is so much easier. all you got to do is have popular music and people will dance, i just turn it up loud and throw popular song after popular song out there. the saturday set is much more about building the set and finding good music people haven't heard before and finding what is going to turn the dance floor on that night and getting the dance floor full and rocking. it feels more like i as a dj have done more and is much more fulfilling.
i noticed it once in a battle of the bands. some of bands rocked their own songs and maybe a hit or two. the winners did a bob marley medley. it thought it was unfair, cause i could rock a bar crowd, with enough drinks in me and my audience, with a bob medley and i can't sing or play an instrument. it really didn't say much about the skill of the band.
anyway as a dj both are cool, but i really like rocking non top 40 music.